Background :
@EN Generalized pustular psoriasis (GPP) is an uncommon from of psoriasis in which a widespread eruption of sterile pustules occurs. In Korea some cases of generalized pustular psoriasis have been reported, but clinical reviews on generalized
pustular
psoriasis are not avalilable.
@ES Objective :
@EN We investegated the clinical and laboratory findings in some patients with generalozed pultulare psoriasis in Korea.
@ES Methods :
@EN We studied the clinical and laboratory findings in 27 patients with generalized pustular psoriasis who visited of patients with generalized pustular psoriasis, and analyzed after the patients were separated into 4 clinical types.
@ES Results :
@EN 1. The male to female ration was 1:2, and the average age of the first onset of GPP was 27.1 years.
2. The number of patients with previous history of psoriasis vulgaris were 19(70.4%). In these patients, the average age at the onset of psoriasis vulgaris was 23.4 years, and average age at the onset of GPP was 34.3 years.
3. The number of patients with a family history of psoriasis were 2(7.4%).
4. The number of patients with possible provocative factors were 16(59.3%). Systemic corticosteroid therapy was done before the onset of GPP in 7 patients, and was the most common provocative factor.
5. Fever(70.4%), clill (33.3%), and arthralgia(18.5%) were common systemic symptoms associated with GPP.
6. In laboratory tests, leukocytosis(63.%), elevated ESR(62.5%), hypoalbuminemia(40.7%), and decreased cdortisol(32.5%) were often found.
7. With the clinical types, the acute generalized type was 59.3%, juvenile and infantile type 25.9%, annular ad circinate type 7.4%, and GPP during pregnancy was 7.4%. In juvenile and infantile type, patients with a previous history of psoriasis
vulgaris and possible provocative factors of GPP were much less common than in the other types.
@ES Conclusion :
@EN In patients with GPP in Korea, a family history of psoriasis is much less frequent than in western countries. In the possible provocative factors of GPP, systemic corticdosteroid therapy was the most common, so it is recommended that systemic
steroid therapy should be avoided in the treatment of psoriasis vulgaris. In the comparison of the 4 clinical types, juvenile and infantile type showed a marked difference in that GPP occurred spontaneously without any previous history of
psoriasis
and
with no provocative factors.
(Kor J Dermatol 1996;34(1) : 233~239)
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